Enzyme Commission (EC) Number Annotations
ec_annotation.RdA reference annotation table mapping Enzyme Commission (EC) numbers to enzyme names. This dataset is used in the tKOI framework to annotate biological network nodes associated with enzymatic activity.
Format
A data frame with 8764 rows and 2 columns:
- identifier
A character string representing the EC number (e.g., "1.1.1.196"). EC numbers classify enzymes by the chemical reactions they catalyze.
- name
The full enzyme name (e.g., "15-hydroxyprostaglandin-D dehydrogenase (NADP+)"). If missing (
NA), the enzyme has an identifier but no corresponding name in the source.
Source
IUBMB Enzyme Nomenclature https://enzyme.expasy.org/
Details
EC numbers are a standardized nomenclature for enzymes, maintained by the IUBMB. This dataset supports functional interpretation of nodes in the tKOI network with enzymatic roles.
The identifier column is used to link to graph nodes of type "EC", and the name column provides descriptive labels for downstream analysis and visualization.
Examples
data(ec_annotation)
subset(ec_annotation, grepl("hydroxylase", name, ignore.case = TRUE))
#> identifier
#> 2 1.14.14.85
#> 8 1.14.15.16
#> 124 1.14.14.71
#> 182 1.17.99.3
#> 189 1.14.13.97
#> 203 1.17.99.10
#> 210 1.14.14.26
#> 313 1.14.14.165
#> 346 1.14.13.172
#> 388 1.14.13.74
#> 482 1.14.14.112
#> 493 1.14.13.159
#> 584 1.14.11.56
#> 733 1.14.14.78
#> 806 1.14.13.73
#> 921 1.14.14.48
#> 933 1.14.14.168
#> 951 1.14.13.99
#> 989 1.14.13.180
#> 1007 1.14.11.39
#> 1146 1.14.11.55
#> 1213 1.14.11.70
#> 1252 1.14.14.146
#> 1253 1.17.99.5
#> 1271 1.14.11.41
#> 1302 1.14.13.191
#> 1312 1.14.14.106
#> 1435 1.14.14.27
#> 1475 1.14.13.240
#> 1502 1.14.99.2
#> 1612 1.14.13.150
#> 1763 1.14.11.40
#> 1783 1.14.14.124
#> 1832 1.14.14.83
#> 1846 1.14.14.145
#> 1854 1.14.14.113
#> 1871 1.14.99.37
#> 1907 1.14.13.152
#> 1933 1.14.13.198
#> 1941 1.14.14.49
#> 1947 1.14.14.178
#> 2109 1.14.14.164
#> 2229 1.14.13.135
#> 2273 1.14.14.29
#> 2360 1.14.13.145
#> 2382 1.14.11.58
#> 2394 1.14.13.94
#> 2404 1.99.1
#> 2415 1.14.13.228
#> 2488 1.14.14.70
#> 2498 1.14.14.158
#> 2512 1.14.14.118
#> 2524 1.14.13.147
#> 2607 1.14.13.220
#> 2634 1.14.11.45
#> 2866 1.14.13.75
#> 2960 1.14.14.121
#> 3000 1.14.11.42
#> 3054 1.14.15.22
#> 3059 1.17.8.1
#> 3063 1.14.13.146
#> 3071 1.14.14.144
#> 3089 1.14.13.63
#> 3176 1.14.13.91
#> 3276 1.14.11.60
#> 3498 1.14.15.27
#> 3514 1.14.14.183
#> 3516 1.17.9.2
#> 3614 1.14.13.219
#> 3630 1.14.14.134
#> 3631 1.14.13.197
#> 3686 1.14.13.181
#> 3729 1.14.14.57
#> 3736 1.14.14.120
#> 3785 1.14.18.8
#> 3845 1.14.11.28
#> 3878 1.14.14.25
#> 3895 1.17.99.2
#> 3931 1.14.13.113
#> 4008 1.14.11.57
#> 4085 1.14.14.54
#> 4090 1.14.14.24
#> 4247 1.14.13.143
#> 4249 1.14.14.182
#> 4359 1.14.13.188
#> 4453 1.14.15.35
#> 4521 1.14.13.119
#> 4588 1.14.99.43
#> 4620 1.14.99.69
#> 4964 1.14.13.123
#> 5020 1.14.11.20
#> 5035 1.14.15.31
#> 5157 1.14.13.100
#> 5176 1.14.11.47
#> 5217 1.14.13.98
#> 5232 1.14.14.136
#> 5262 1.14.13.127
#> 5333 1.14.99.60
#> 5377 1.14.14.139
#> 5395 1.14.14.138
#> 5554 1.14.13.189
#> 5583 1.14.13.109
#> 5752 1.14.13.154
#> 5807 1.14.13.161
#> 5808 1.14.13.77
#> 5895 1.17.3.4
#> 5909 1.14.15.10
#> 6045 1.14.13.209
#> 6054 1.14.15.19
#> 6172 1.17.1.6
#> 6256 1.14.11.61
#> 6278 1.14.14.125
#> 6316 1.14.14.79
#> 6357 1.14.13.199
#> 6409 1.14.99.65
#> 6579 1.17.98.1
#> 6683 1.14.14.95
#> 6745 1.14.13.176
#> 6786 1.14.11.76
#> 6801 1.14.13.153
#> 6809 1.14.15.14
#> 6828 1.14.13.64
#> 6861 1.14.14.103
#> 6961 1.14.11.73
#> 7037 1.14.14.176
#> 7175 1.14.13.95
#> 7239 1.14.13.126
#> 7254 1.14.13.108
#> 7347 1.14.11.35
#> 7353 1.14.14.105
#> 7370 1.14.13.76
#> 7474 1.17.2.2
#> 7511 1.14.14.149
#> 7577 1.7.3.3
#> 7581 1.14.11.71
#> 7677 1.14.14.162
#> 7704 1.14.13.184
#> 7723 1.14.99.49
#> 7736 1.14.14.76
#> 7775 1.14.14.171
#> 7960 1.14.13.194
#> 7970 1.14.11.79
#> 8035 1.14.13.96
#> 8205 1.14.13.110
#> 8233 1.14.14.177
#> 8293 1.14.13.183
#> 8327 1.14.14.104
#> 8364 1.14.14.166
#> 8421 1.14.14.167
#> 8430 1.14.14.163
#> 8449 1.5.99.4
#> name
#> 2 7-deoxyloganate 7-hydroxylase
#> 8 vitamin D3 24-hydroxylase
#> 124 cucurbitadienol 11-hydroxylase
#> 182 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase
#> 189 taurochenodeoxycholate 6alpha-hydroxylase
#> 203 steroid C-25 hydroxylase
#> 210 24-hydroxycholesterol 7alpha-hydroxylase
#> 313 indole-3-carbonyl nitrile 4-hydroxylase
#> 346 salicylate 5-hydroxylase
#> 388 7-deoxyloganin 7-hydroxylase
#> 482 ent-cassa-12,15-diene 11-hydroxylase
#> 493 vitamin D 25-hydroxylase
#> 584 L-proline cis-4-hydroxylase
#> 733 phylloquinone omega-hydroxylase
#> 806 tabersonine 16-hydroxylase
#> 921 jasmonoyl-L-amino acid 12-hydroxylase
#> 933 germacrene A acid 8beta-hydroxylase
#> 951 24-hydroxycholesterol 7alpha-hydroxylase
#> 989 aklavinone 12-hydroxylase
#> 1007 L-asparagine hydroxylase
#> 1146 ectoine hydroxylase
#> 1213 7-deoxycylindrospermopsin hydroxylase
#> 1252 geranylgeraniol 18-hydroxylase
#> 1253 bile-acid 7alpha-dehydroxylase
#> 1271 L-arginine hydroxylase
#> 1302 ent-sandaracopimaradiene 3-hydroxylase
#> 1312 taxane 13alpha-hydroxylase
#> 1435 resorcinol 4-hydroxylase (FADH2)
#> 1475 2-polyprenylphenol 6-hydroxylase
#> 1502 kynurenine 7,8-hydroxylase
#> 1612 alpha-humulene 10-hydroxylase
#> 1763 enduracididine beta-hydroxylase
#> 1783 dihydromonacolin L hydroxylase
#> 1832 geraniol 8-hydroxylase
#> 1846 abieta-7,13-dien-18-ol hydroxylase
#> 1854 alpha-humulene 10-hydroxylase
#> 1871 taxadiene 5alpha-hydroxylase
#> 1907 geraniol 8-hydroxylase
#> 1933 monacolin L hydroxylase
#> 1941 12-hydroxyjasmonoyl-L-amino acid 12-hydroxylase
#> 1947 steroid 22S-hydroxylase
#> 2109 fraxetin 5-hydroxylase
#> 2229 1-hydroxy-2-naphthoate hydroxylase
#> 2273 25/26-hydroxycholesterol 7alpha-hydroxylase
#> 2360 ent-cassa-12,15-diene 11-hydroxylase
#> 2382 ornithine lipid ester-linked acyl 2-hydroxylase
#> 2394 lithocholate 6beta-hydroxylase
#> 2404 Hydroxylases (now covered by EC 1.14)
#> 2415 jasmonic acid 12-hydroxylase
#> 2488 ent-sandaracopimaradiene 3-hydroxylase
#> 2498 carotenoid epsilon hydroxylase
#> 2512 tryprostatin B 6-hydroxylase
#> 2524 taxoid 7beta-hydroxylase
#> 2607 resorcinol 4-hydroxylase (NADH)
#> 2634 L-isoleucine 4-hydroxylase
#> 2866 vinorine hydroxylase
#> 2960 protopanaxadiol 6-hydroxylase
#> 3000 tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase
#> 3054 vitamin D 1,25-hydroxylase
#> 3059 hydroxysqualene dehydroxylase
#> 3063 taxoid 14beta-hydroxylase
#> 3071 abieta-7,13-diene hydroxylase
#> 3089 3-hydroxyphenylacetate 6-hydroxylase
#> 3176 deoxysarpagine hydroxylase
#> 3276 scopoletin 8-hydroxylase
#> 3498 beta-dihydromenaquinone-9 omega-hydroxylase
#> 3514 taxoid 2alpha-hydroxylase
#> 3516 (+)-pinoresinol hydroxylase
#> 3614 resorcinol 4-hydroxylase (NADPH)
#> 3630 beta-amyrin 24-hydroxylase
#> 3631 dihydromonacolin L hydroxylase
#> 3686 13-deoxydaunorubicin hydroxylase
#> 3729 taurochenodeoxycholate 6alpha-hydroxylase
#> 3736 dammarenediol 12-hydroxylase
#> 3785 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase
#> 3845 proline 3-hydroxylase
#> 3878 cholesterol 24-hydroxylase
#> 3895 ethylbenzene hydroxylase
#> 3931 FAD-dependent urate hydroxylase
#> 4008 L-proline trans-4-hydroxylase
#> 4085 phenylacetate 2-hydroxylase
#> 4090 vitamin D 25-hydroxylase
#> 4247 ent-isokaurene C2/3-hydroxylase
#> 4249 taxoid 7beta-hydroxylase
#> 4359 6-deoxyerythronolide B hydroxylase
#> 4453 6-deoxyerythronolide B hydroxylase
#> 4521 5-epiaristolochene 1,3-dihydroxylase
#> 4588 beta-amyrin 24-hydroxylase
#> 4620 tRNA 2-(methylsulfanyl)-N6-isopentenyladenosine37 hydroxylase
#> 4964 germacrene A hydroxylase
#> 5020 deacetoxyvindoline 4-hydroxylase
#> 5035 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase
#> 5157 25/26-hydroxycholesterol 7alpha-hydroxylase
#> 5176 [50S ribosomal protein L16]-arginine 3-hydroxylase
#> 5217 cholesterol 24-hydroxylase
#> 5232 deoxysarpagine hydroxylase
#> 5262 3-(3-hydroxyphenyl)propanoate hydroxylase
#> 5333 3-demethoxyubiquinol 3-hydroxylase
#> 5377 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase
#> 5395 lithocholate 6beta-hydroxylase
#> 5554 5-methyl-1-naphthoate 3-hydroxylase
#> 5583 abieta-7,13-dien-18-ol hydroxylase
#> 5752 erythromycin 12-hydroxylase
#> 5807 (+)-camphor 6-exo-hydroxylase
#> 5808 taxane 13alpha-hydroxylase
#> 5895 juglone 3-hydroxylase
#> 5909 (+)-camphor 6-endo-hydroxylase
#> 6045 salicyloyl-CoA 5-hydroxylase
#> 6054 C-19 steroid 1alpha-hydroxylase
#> 6172 bile-acid 7alpha-dehydroxylase
#> 6256 feruloyl-CoA 6-hydroxylase
#> 6278 monacolin L hydroxylase
#> 6316 docosahexaenoic acid omega-hydroxylase
#> 6357 docosahexaenoic acid omega-hydroxylase
#> 6409 4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] 3-hydroxylase
#> 6579 bile-acid 7alpha-dehydroxylase
#> 6683 germacrene A hydroxylase
#> 6745 tryprostatin B 6-hydroxylase
#> 6786 L-glutamate 3(R)-hydroxylase
#> 6801 (+)-sabinene 3-hydroxylase
#> 6809 methyl-branched lipid omega-hydroxylase
#> 6828 4-hydroxybenzoate 1-hydroxylase
#> 6861 tabersonine 16-hydroxylase
#> 6961 [protein]-arginine 3-hydroxylase
#> 7037 taxadiene 5alpha-hydroxylase
#> 7175 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase
#> 7239 vitamin D3 24-hydroxylase
#> 7254 abieta-7,13-diene hydroxylase
#> 7347 1-deoxypentalenic acid 11beta-hydroxylase
#> 7353 taxane 10beta-hydroxylase
#> 7370 taxane 10beta-hydroxylase
#> 7474 lupanine 17-hydroxylase (cytochrome c)
#> 7511 5-epiaristolochene 1,3-dihydroxylase
#> 7577 factor-independent urate hydroxylase
#> 7581 methylphosphonate hydroxylase
#> 7677 flavanone 2-hydroxylase
#> 7704 protopanaxadiol 6-hydroxylase
#> 7723 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase
#> 7736 ent-isokaurene C2/C3-hydroxylase
#> 7775 beta-amyrin 16alpha-hydroxylase
#> 7960 phylloquinone omega-hydroxylase
#> 7970 protein-L-histidine (3S)-3-hydroxylase
#> 8035 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase
#> 8205 geranylgeraniol 18-hydroxylase
#> 8233 ultra-long-chain fatty acid omega-hydroxylase
#> 8293 dammarenediol 12-hydroxylase
#> 8327 vinorine hydroxylase
#> 8364 (S)-N-methylcanadine 1-hydroxylase
#> 8421 (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase
#> 8430 (S)-1-hydroxy-N-methylcanadine 13-hydroxylase
#> 8449 nicotine 6-hydroxylase