Pathway Group Annotations (Reactome Interaction Sets)
pwgroup_annotation.RdA curated annotation table for grouped pathway interaction events from Reactome. Each entry represents a molecular interaction or signaling complex involved in a pathway context, typically grouped by protein complexes or ligand-receptor interactions. These pathway groupings support detailed annotation of graph nodes in the tKOI network that represent composite signaling units.
Format
A data frame with 6343 rows and 2 columns:
- identifier
A character string representing the Reactome stable identifier (e.g., "reactome:R-HSA-9624419").
- name
A human-readable description of the interaction group or signaling unit (e.g., "EGFR:EGF-like ligands").
Source
Reactome Pathway Database https://reactome.org
Details
This dataset provides molecular resolution for pathway-associated interactions and groupings (e.g., dimerized receptors, ligand-bound complexes), enhancing the interpretability of nodes labeled as "PwGroup" in tKOI analyses. These groups often represent intermediate or context-specific biochemical states within signaling cascades.
The identifier field can be used to join with graph nodes, while the name field is useful for labeling and summarizing pathway-level results.
Examples
data(pwgroup_annotation)
subset(pwgroup_annotation, grepl("EGFR", name))
#> identifier
#> 2 reactome:R-HSA-9674862
#> 3 reactome:R-HSA-9624419
#> 4 reactome:R-HSA-9624420
#> 5 reactome:R-HSA-9624425
#> 6 reactome:R-HSA-212717
#> 7 reactome:R-HSA-212703
#> 9 reactome:R-HSA-179820
#> 12 reactome:R-HSA-9624427
#> 13 reactome:R-HSA-180337
#> 14 reactome:R-HSA-180331
#> 18 reactome:R-HSA-180348
#> 19 reactome:R-HSA-180286
#> 24 reactome:R-HSA-179791
#> 25 reactome:R-HSA-180269
#> 26 reactome:R-HSA-180503
#> 30 reactome:R-HSA-180326
#> 31 reactome:R-HSA-180343
#> 32 reactome:R-HSA-180277
#> 35 reactome:R-HSA-182960
#> 36 reactome:R-HSA-182953
#> 37 reactome:R-HSA-182939
#> 39 reactome:R-HSA-182930
#> 41 reactome:R-HSA-182928
#> 42 reactome:R-HSA-182948
#> 43 reactome:R-HSA-182945
#> 49 reactome:R-HSA-182946
#> 56 reactome:R-HSA-8951489
#> 57 reactome:R-HSA-182932
#> 60 reactome:R-HSA-182961
#> 61 reactome:R-HSA-182935
#> 62 reactome:R-HSA-182936
#> 65 reactome:R-HSA-182931
#> 66 reactome:R-HSA-179882
#> 67 reactome:R-HSA-179860
#> 68 reactome:R-HSA-8864028
#> 69 reactome:R-HSA-8864018
#> 70 reactome:R-HSA-8867034
#> 71 reactome:R-HSA-8867035
#> 531 reactome:R-HSA-195398
#> 534 reactome:R-HSA-195403
#> 537 reactome:R-HSA-195405
#> 539 reactome:R-HSA-195402
#> 541 reactome:R-HSA-4420101
#> 542 reactome:R-HSA-4420096
#> 543 reactome:R-HSA-4420196
#> 544 reactome:R-HSA-4420164
#> 545 reactome:R-HSA-4420141
#> 546 reactome:R-HSA-5218639
#> 547 reactome:R-HSA-5218641
#> 548 reactome:R-HSA-5218636
#> 549 reactome:R-HSA-5218635
#> 551 reactome:R-HSA-5218779
#> 552 reactome:R-HSA-5218637
#> 557 reactome:R-HSA-5218775
#> 558 reactome:R-HSA-5218771
#> 559 reactome:R-HSA-5218787
#> 560 reactome:R-HSA-5218778
#> 561 reactome:R-HSA-5218757
#> 562 reactome:R-HSA-5218760
#> 563 reactome:R-HSA-5218781
#> 564 reactome:R-HSA-5218756
#> 565 reactome:R-HSA-5218790
#> 566 reactome:R-HSA-5218762
#> 567 reactome:R-HSA-5218759
#> 568 reactome:R-HSA-5218765
#> 570 reactome:R-HSA-5218776
#> 574 reactome:R-HSA-4420171
#> 575 reactome:R-HSA-4420137
#> 576 reactome:R-HSA-4420169
#> 577 reactome:R-HSA-5218788
#> 578 reactome:R-HSA-5357442
#> 579 reactome:R-HSA-5357462
#> 580 reactome:R-HSA-5357453
#> 581 reactome:R-HSA-5218777
#> 615 reactome:R-HSA-5218798
#> 616 reactome:R-HSA-5218786
#> 617 reactome:R-HSA-5218795
#> 618 reactome:R-HSA-5218780
#> 619 reactome:R-HSA-5218766
#> 622 reactome:R-HSA-5218782
#> 624 reactome:R-HSA-5218792
#> 627 reactome:R-HSA-5218793
#> 631 reactome:R-HSA-4420203
#> 632 reactome:R-HSA-4420110
#> 643 reactome:R-HSA-195419
#> 644 reactome:R-HSA-195427
#> 688 reactome:R-HSA-1963571
#> 689 reactome:R-HSA-179847
#> 695 reactome:R-HSA-1227939
#> 701 reactome:R-HSA-1810434
#> 705 reactome:R-HSA-1248703
#> 706 reactome:R-HSA-1248702
#> 713 reactome:R-HSA-1963593
#> 728 reactome:R-HSA-1963587
#> 729 reactome:R-HSA-1250505
#> 736 reactome:R-HSA-1306958
#> 737 reactome:R-HSA-1306961
#> 738 reactome:R-HSA-1306962
#> 739 reactome:R-HSA-1251942
#> 749 reactome:R-HSA-8863840
#> 752 reactome:R-HSA-8863834
#> 755 reactome:R-HSA-8864106
#> 756 reactome:R-HSA-8864118
#> 757 reactome:R-HSA-8864120
#> 758 reactome:R-HSA-8864124
#> 759 reactome:R-HSA-8864121
#> 778 reactome:R-HSA-1977956
#> 1532 reactome:R-HSA-2179410
#> 1533 reactome:R-HSA-2179388
#> 1534 reactome:R-HSA-2179409
#> 1729 reactome:R-HSA-9018569
#> 2256 reactome:R-HSA-9625453
#> 2257 reactome:R-HSA-9625464
#> 2941 reactome:R-HSA-8857547
#> 2942 reactome:R-HSA-8857546
#> 2943 reactome:R-HSA-8857556
#> 2944 reactome:R-HSA-8857567
#> 2945 reactome:R-HSA-8857574
#> 3135 reactome:R-HSA-1218825
#> 3136 reactome:R-HSA-1220581
#> 3137 reactome:R-HSA-1220583
#> 3138 reactome:R-HSA-1220578
#> 3139 reactome:R-HSA-1220573
#> 3140 reactome:R-HSA-1220580
#> 3141 reactome:R-HSA-1500847
#> 3142 reactome:R-HSA-1500849
#> 3143 reactome:R-HSA-1220582
#> 3144 reactome:R-HSA-1181062
#> 3145 reactome:R-HSA-1220652
#> 3146 reactome:R-HSA-1220648
#> 3147 reactome:R-HSA-1809164
#> 3148 reactome:R-HSA-1809167
#> 3149 reactome:R-HSA-1220654
#> 3150 reactome:R-HSA-1220650
#> 3151 reactome:R-HSA-1809168
#> 3152 reactome:R-HSA-1809170
#> 3153 reactome:R-HSA-1225859
#> 3154 reactome:R-HSA-1225858
#> 3155 reactome:R-HSA-1225854
#> 3156 reactome:R-HSA-1225856
#> 3157 reactome:R-HSA-1226015
#> 3158 reactome:R-HSA-1226013
#> 3159 reactome:R-HSA-1247845
#> 3160 reactome:R-HSA-1247846
#> 3161 reactome:R-HSA-1225855
#> 3162 reactome:R-HSA-1225857
#> 3164 reactome:R-HSA-1220585
#> 3165 reactome:R-HSA-1220574
#> 3166 reactome:R-HSA-1220575
#> 3167 reactome:R-HSA-1220587
#> 3168 reactome:R-HSA-1220572
#> 3169 reactome:R-HSA-1220571
#> 3170 reactome:R-HSA-1181059
#> 3171 reactome:R-HSA-1220579
#> 3172 reactome:R-HSA-1248004
#> 3173 reactome:R-HSA-1248010
#> 3174 reactome:R-HSA-1248654
#> 3175 reactome:R-HSA-1248651
#> 3176 reactome:R-HSA-5637697
#> 3177 reactome:R-HSA-5637701
#> 3178 reactome:R-HSA-5637703
#> 3179 reactome:R-HSA-5637704
#> 3180 reactome:R-HSA-5637694
#> 3181 reactome:R-HSA-5637693
#> 3182 reactome:R-HSA-5637698
#> 3183 reactome:R-HSA-5637706
#> 3184 reactome:R-HSA-1248675
#> 3185 reactome:R-HSA-1225979
#> 3395 reactome:R-HSA-9646489
#> 3396 reactome:R-HSA-9654429
#> 3397 reactome:R-HSA-9654438
#> 3399 reactome:R-HSA-9664564
#> 3400 reactome:R-HSA-9664561
#> 3401 reactome:R-HSA-9664562
#> 3403 reactome:R-HSA-9664609
#> 3404 reactome:R-HSA-9664598
#> 3405 reactome:R-HSA-9664604
#> 3406 reactome:R-HSA-9664613
#> 3407 reactome:R-HSA-9664603
#> 3408 reactome:R-HSA-9664614
#> 3417 reactome:R-HSA-9664917
#> 3418 reactome:R-HSA-9664921
#> 3419 reactome:R-HSA-9664932
#> 3423 reactome:R-HSA-9665001
#> 3424 reactome:R-HSA-9664996
#> 3425 reactome:R-HSA-9665037
#> 3426 reactome:R-HSA-9665033
#> 3438 reactome:R-HSA-9665391
#> 3439 reactome:R-HSA-9665380
#> 3442 reactome:R-HSA-9665436
#> 3443 reactome:R-HSA-9665441
#> 3444 reactome:R-HSA-9665437
#> 3445 reactome:R-HSA-9665449
#> 3446 reactome:R-HSA-9665446
#> 3447 reactome:R-HSA-9665453
#> 3448 reactome:R-HSA-9665460
#> 3450 reactome:R-HSA-9665867
#> 3451 reactome:R-HSA-9665877
#> 3452 reactome:R-HSA-9665910
#> 3453 reactome:R-HSA-9665887
#> 3454 reactome:R-HSA-9665882
#> 3455 reactome:R-HSA-9665869
#> 3456 reactome:R-HSA-9665917
#> 3457 reactome:R-HSA-9665916
#> 3458 reactome:R-HSA-9665925
#> 3459 reactome:R-HSA-9665924
#> name
#> 2 EGFR:AAMP
#> 3 EGFR:EGF-like ligands
#> 4 EGF-like ligands:EGFR dimer
#> 5 EGF-like ligands:p-6Y EGFR dimer
#> 6 Activated EGFR:PLC-gamma1
#> 7 Activated EGFR:Phospho-PLC-gamma1
#> 9 GRB2:SOS-EGF-Phospho-EGFR dimer
#> 12 EGF-like ligands:p-6Y EGFR:SHC1
#> 13 EGF:Phospho-EGFR:Phospho-SHC
#> 14 GRB2:SOS-Phospho-SHC:EGF:Phospho-EGFR dimer
#> 18 GAB1:GRB2-EGF-Phospho-EGFR dimer
#> 19 GRB2:Phospho GAB1-EGF-Phospho-EGFR dimer
#> 24 EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K
#> 25 SHP2-GRB2:Phospho GAB1-EGF-Phospho-EGFR dimer
#> 26 EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2
#> 30 EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2
#> 31 EGF-like ligands:Phospho-EGFR (-Y992) dimer
#> 32 EGF-like ligands:Phospho-EGFR (- Y992)
#> 35 EGF-like ligands:p-6Y-EGFR:CBL
#> 36 EGF-like ligands:p-6Y-EGFR:p-Y371-CBL
#> 37 EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2
#> 39 EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL
#> 41 EGF-like ligands:p-6Y-EGFR:CBL:GRB2
#> 42 EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2
#> 43 EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2
#> 49 EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin
#> 56 EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85
#> 57 EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP
#> 60 EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15
#> 61 EGF:Phospho-EGFR dimer:CBL:Phospho-Sprouty
#> 62 EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15
#> 65 EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15
#> 66 EGF:p-6Y-EGFR dimer
#> 67 EGF:Phospho-EGFR
#> 68 EGF:p-EGFR dimer dephosphorylated at Y1172 (Y1148)
#> 69 EGF:p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR
#> 70 EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM
#> 71 EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM
#> 531 VEGFR1 dimer
#> 534 VEGFR2 dimer
#> 537 VEGFR3 dimer
#> 539 VEGFA-165 dimer:VEGFR2
#> 541 VEGFA dimer:p-6Y-VEGFR2 dimer
#> 542 p-6Y-VEGFR2 dimer
#> 543 VEGFA dimer:p-6Y-VEGFR2 dimer:SHB
#> 544 VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB
#> 545 VEGFA:p-6Y-VEGFR2:p-SHB:PTK2
#> 546 VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2
#> 547 VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1
#> 548 VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1
#> 549 VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2
#> 551 VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3
#> 552 VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1
#> 557 VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1
#> 558 VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2
#> 559 VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:PTK2B
#> 560 VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:p-Y402-PTK2B
#> 561 VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1
#> 562 VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2
#> 563 VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN
#> 564 VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN
#> 565 VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1:BCAR1
#> 566 VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1
#> 567 VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN
#> 568 VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK
#> 570 CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN
#> 574 VEGFA:p-6Y-VEGFR2:SHC2
#> 575 VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A
#> 576 VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1
#> 577 VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1
#> 578 VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXL
#> 579 VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL
#> 580 VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K
#> 581 VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K
#> 615 VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2
#> 616 VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN
#> 617 VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN
#> 618 VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN
#> 619 VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2
#> 622 VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP
#> 624 VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP
#> 627 VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP
#> 631 VEGFA dimer:p-6Y-VEGFR2 dimer:PLCG1
#> 632 VEGFA dimer:p-6Y-VEGFR2 dimer:p-4Y-PLCG1
#> 643 NRP1:VEGFR2 dimer
#> 644 NRP2:VEGFR1 dimer
#> 688 Ligand-Activated EGFR/ERBB3/ERBB4
#> 689 EGF:EGFR
#> 695 EGF:EGFR:ERBB2
#> 701 EGF:EGFR:p-Y877-ERBB2
#> 705 EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2
#> 706 EGF:p-6Y-EGFR
#> 713 EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2
#> 728 Phosphorylated ERBB2:EGFR heterodimers
#> 729 GRB2:SOS1:P-ERBB2:P-EGFR
#> 736 EGF:p-EGFR:p-ERBB2:GRB2:GAB1
#> 737 PI3K:GRB2:GAB1:P-ERBB2:P-EGFR
#> 738 PI3Kp85:GRB2:GAB1:P-ERBB2:P-EGFR
#> 739 EGF:p-EGFR:p-ERBB2:PLCG1
#> 749 EGF:p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR:p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2
#> 752 EGF:p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR:p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2
#> 755 Phosphorylated ERBB2:EGFR heterodimers:PTPN18
#> 756 Phosphorylated ERBB2(dephosphorylated at Y1196,Y1112 and Y1248):EGFR heterodimers:PTPN18
#> 757 Phosphorylated ERBB2(dephosphorylated at Y1196,Y1112 and Y1248):EGFR heterodimers
#> 758 EGF:p-6Y-EGFR:p-Y1023,Y1139,Y1221,Y1222-ERBB2
#> 759 EGF:p-6Y-EGFR:p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2
#> 778 ERBB4:EGFR heterodimer
#> 1532 HB-EGF:p-6Y-EGFR dimer
#> 1533 HB-EGF:p-6Y-EGFR
#> 1534 GRB2:SOS1:HB-EGF:p-6Y-EGFR
#> 1729 EGF:p-6Y-EGFR dimer:NICD3
#> 2256 EGF-like ligands:p-6Y EGFR:PTK2
#> 2257 EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2
#> 2941 HBEGF:EGFR
#> 2942 HBEGF:EGFR:GPNMB
#> 2943 HBEGF:EGFR:p-Y525-GPNMB
#> 2944 HBEGF:EGFR:p-Y525-GPNMB:LINC01139:PTK6:LRRK2
#> 2945 HBEGF:EGFR:p-Y525-GPNMB:LINC01139:p-Y351-PTK6:LRRK2
#> 3135 Ligand-responsive EGFR mutants:HSP90:CDC37
#> 3136 Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37
#> 3137 Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37
#> 3138 EGF:Ligand-responsive EGFR mutants:HSP90:CDC37
#> 3139 EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37
#> 3140 EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37
#> 3141 EGF:Ligand-responsive EGFR mutants dimer
#> 3142 Ligand-responsive EGFR mutants dimer
#> 3143 Active dimers of ligand-responsive EGFR mutants
#> 3144 Ligand-responsive p-6Y-EGFR mutant dimers
#> 3145 Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants
#> 3146 EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37
#> 3147 EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37
#> 3148 EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37
#> 3149 Dimers of ligand-responsive p-6Y-EGFR mutants
#> 3150 Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37
#> 3151 Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37
#> 3152 Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37
#> 3153 GRB2:SOS1:Phospho-EGFRmutKD:HSP90:CDC37
#> 3154 Ligand-responsive p-6Y-EGFR mutants:SHC1
#> 3155 Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1
#> 3156 GRB2:SOS1:Phospho-SHC1:Phospho-EGFRmutKD:HSP90:CDC37
#> 3157 Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1
#> 3158 Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1:PI3K
#> 3159 Phospho-EGFRmutKD:PLCgamma1
#> 3160 Ligand-responsive p-6Y-EGFR mutants:p-Y472,771,783,1254-PLCG1
#> 3161 Ligand-responsive p-6Y-EGFR mutants:CBL
#> 3162 Ligand-responsive p-6Y-EGFR mutants:p-Y371-CBL
#> 3164 Resistant ligand-responsive EGFR mutants
#> 3165 Dimers of EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs
#> 3166 Dimers of ligand-responsive EGFR mutants resistant to non-covalent TKIs
#> 3167 Sensitive ligand-responsive EGFR mutants:Non-covalent EGFR TKIs
#> 3168 Active dimers of ligand-responsive EGFR mutants sensitive to non-covalent TKIs
#> 3169 Dimers of EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs
#> 3170 Dimers of ligand-responsive EGFR mutants sensitive to non-covalent TKIs
#> 3171 Resistant ligand-responsive EGFR mutants:Covalent EGFR TKIs
#> 3172 EGFRvIIImut:HSP90:CDC37
#> 3173 EGFRvIII mutant dimer
#> 3174 p-5Y-EGFRvIII mutant dimer
#> 3175 Phospho-EGFRvIIImut:HSP90:CDC37
#> 3176 p-5Y-EGFRvIII:GRB2:SOS1
#> 3177 p-5Y-EGFRvIII:SHC1
#> 3178 p-5Y-EGFRvIII:p-Y349,Y350-SHC1
#> 3179 p-5Y-EGFRvIII:p-Y349,Y350-SHC1:GRB2:SOS1
#> 3180 p-5Y-EGFRvIII:GRB2:GAB1
#> 3181 p-5Y-EGFRvIII:GRB2:GAB1:PI3K
#> 3182 p-5Y-EGFRvIII:PLCG1
#> 3183 p-5Y-EGFRvIII:p-Y771,Y783,Y1254-PLCG1
#> 3184 EGFR:Cetuximab
#> 3185 EGF:EGFR Dimer:irrevTKIs
#> 3395 Ligand-Activated EGFR,ERBB3,(ERBB4)
#> 3396 Ligand-Activated EGFR,(ERBB3,ERBB4)
#> 3397 Ligand-Activated ERBB3,(EGFR,ERBB4)
#> 3399 ERBB2 KD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4)
#> 3400 ERBB2 KD mutants:Ligand-Activated EGFR,(ERBB3,ERBB4)
#> 3401 ERBB2 KD mutants:Ligand-Activated ERBB3,(EGFR,ERBB4)
#> 3403 p-6Y-ERBB2 KD mutants:Ligand-Activated p-EGFR,(p-ERBB3,p-ERBB4)
#> 3404 Ligand-Activated p-EGFR,(p-ERBB3,p-ERBB4)
#> 3405 p-6Y-ERBB2 KD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4)
#> 3406 Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4)
#> 3407 p-6Y-ERBB2 KD mutants:Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4)
#> 3408 Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4)
#> 3417 p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR
#> 3418 p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:GRB2:GAB1
#> 3419 p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:GRB2:GAB1:PI3K
#> 3423 p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR
#> 3424 p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:GRB2:SOS1
#> 3425 p-6Y-ERBB2 KD mutants (PLCG1):EGF:p-6Y-EGFR
#> 3426 p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:PLCG1
#> 3438 ERBB2 ECD mutants:EGF:EGFR
#> 3439 p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR
#> 3442 p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:SHC1
#> 3443 p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-Y349,Y350-SHC1
#> 3444 p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-Y349,Y350-SHC1:GRB2:SOS1
#> 3445 p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:SOS1
#> 3446 p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:GAB1
#> 3447 p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:GAB1:PI3K
#> 3448 p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:PLCG1
#> 3450 ERBB2 TMD/JMD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4)
#> 3451 p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4)
#> 3452 p-6Y-ERBB2 TMD/JMD mutants (RAS):Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4)
#> 3453 p-6Y-ERBB2 TMD/JMD mutants (RAS):Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):SHC1
#> 3454 p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):p-SHC1
#> 3455 p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):p-SHC1:GRB2:SOS1
#> 3456 p-6Y-ERBB2 TMD/JMD mutants (RAS):EGF:p-6Y-EGFR
#> 3457 p-6Y-ERBB2 TMD/JMD mutants (RAS):EGF:p-6Y-EGFR:GRB2:SOS1
#> 3458 p-6Y-ERBB2 R678Q:EGF:p-6Y-EGFR
#> 3459 p-6Y-ERBB2 R678Q:EGF:p-6Y-EGFR:PLCG1