Enzyme Commission (EC) Number Annotations

A reference annotation table mapping Enzyme Commission (EC) numbers to enzyme names. This dataset is used in the pKOI framework to annotate biological network nodes associated with enzymatic activity.

Usage

ec_annotation

Format

A data frame with 8764 rows and 2 columns:

identifier

A character string representing the EC number (e.g., "1.1.1.196"). EC numbers classify enzymes by the chemical reactions they catalyze.

name

The full enzyme name (e.g., "15-hydroxyprostaglandin-D dehydrogenase (NADP+)"). If missing (`NA`), the enzyme has an identifier but no corresponding name in the source.

Source

IUBMB Enzyme Nomenclature https://enzyme.expasy.org/

Details

EC numbers are a standardized nomenclature for enzymes, maintained by the IUBMB. This dataset supports functional interpretation of nodes in the pKOI network with enzymatic roles. The `identifier` column is used to link to graph nodes of type "EC", and the `name` column provides descriptive labels for downstream analysis and visualization.

Examples

data(ec_annotation)
subset(ec_annotation, grepl("hydroxylase", name, ignore.case = TRUE)) |> head()
#>     identifier
#> 2   1.14.14.85
#> 8   1.14.15.16
#> 124 1.14.14.71
#> 182  1.17.99.3
#> 189 1.14.13.97
#> 203 1.17.99.10
#>                                                                       name
#> 2                                            7-deoxyloganate 7-hydroxylase
#> 8                                                vitamin D3 24-hydroxylase
#> 124                                         cucurbitadienol 11-hydroxylase
#> 182 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase
#> 189                              taurochenodeoxycholate 6alpha-hydroxylase
#> 203                                               steroid C-25 hydroxylase