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Pathway Group Annotations (Reactome Interaction Sets)

pwgroup_annotation.Rd

A curated annotation table for grouped pathway interaction events from Reactome. Each entry represents a molecular interaction or signaling complex involved in a pathway context, typically grouped by protein complexes or ligand-receptor interactions. These pathway groupings support detailed annotation of graph nodes in the pKOI network that represent composite signaling units.

Usage

pwgroup_annotation

Format

A data frame with 6343 rows and 2 columns:

identifier

A character string representing the Reactome stable identifier (e.g., "reactome:R-HSA-9624419").

name

A human-readable description of the interaction group or signaling unit (e.g., "EGFR:EGF-like ligands").

Source

Reactome Pathway Database https://reactome.org

Details

This dataset provides molecular resolution for pathway-associated interactions and groupings (e.g., dimerized receptors, ligand-bound complexes), enhancing the interpretability of nodes labeled as "PwGroup" in pKOI analyses. These groups often represent intermediate or context-specific biochemical states within signaling cascades.

The `identifier` field can be used to join with graph nodes, while the `name` field is useful for labeling and summarizing pathway-level results.

Examples

data(pwgroup_annotation)
subset(pwgroup_annotation, grepl("EGFR", name)) |> head()
#>               identifier                              name
#> 2 reactome:R-HSA-9674862                         EGFR:AAMP
#> 3 reactome:R-HSA-9624419             EGFR:EGF-like ligands
#> 4 reactome:R-HSA-9624420       EGF-like ligands:EGFR dimer
#> 5 reactome:R-HSA-9624425  EGF-like ligands:p-6Y EGFR dimer
#> 6  reactome:R-HSA-212717         Activated EGFR:PLC-gamma1
#> 7  reactome:R-HSA-212703 Activated EGFR:Phospho-PLC-gamma1